Lipid membrane composition influences drug release from dioleoylphosphatidylethanolamine-based liposomes on exposure to ultrasound

Int J Pharm. 2011 Mar 15;406(1-2):114-6. doi: 10.1016/j.ijpharm.2010.12.026. Epub 2010 Dec 24.

Abstract

The effect of membrane composition on calcein release from dioleoylphosphatidylethanolamine (DOPE)-based liposomes on exposure to low doses of 1.13 MHz focused ultrasound (US) was investigated by multivariate analysis, with the goal of designing liposomes for US-mediated drug delivery. Regression analysis revealed a strong correlation between sonosensitivity and the non-bilayer forming lipids DOPE and pegylated distearoylphosphatidylethanolamine (DSPE-PEG 2000), with DOPE having the strongest impact. Unlike most of the previously studied distearoylphosphatidylethanolamine (DSPE)-based liposomes, all the current DOPE-based liposome formulations were found stable in 20% serum in terms of drug retention.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / administration & dosage*
  • Antineoplastic Agents / chemistry
  • Drug Stability
  • Fluoresceins / chemistry
  • Liposomes
  • Models, Chemical
  • Multivariate Analysis
  • Phosphatidylethanolamines / chemistry*
  • Polyethylene Glycols / chemistry
  • Regression Analysis
  • Ultrasonics*

Substances

  • 1,2-distearoyl-sn-glycero-3-phosphoethanolamine-N-methoxy-poly(ethylene glycol 2000)
  • Antineoplastic Agents
  • Fluoresceins
  • Liposomes
  • Phosphatidylethanolamines
  • dioleoyl phosphatidylethanolamine
  • Polyethylene Glycols
  • fluorexon