Synthetic approaches to the 2009 new drugs

Kevin K-C Liu; Subas M Sakya; Christopher J O'Donnell; Andrew C Flick; Jin Li

doi:10.1016/j.bmc.2010.12.038

Synthetic approaches to the 2009 new drugs

Bioorg Med Chem. 2011 Feb 1;19(3):1136-54. doi: 10.1016/j.bmc.2010.12.038. Epub 2010 Dec 24.

Authors

Kevin K-C Liu¹, Subas M Sakya, Christopher J O'Donnell, Andrew C Flick, Jin Li

Affiliation

¹ Pfizer Inc., La Jolla, CA 92037, USA. Kevin.k.liu@pfizer.com

PMID: 21256756
DOI: 10.1016/j.bmc.2010.12.038

Abstract

New drugs are introduced to the market every year and each individual drug represents a privileged structure for its biological target. These new chemical entities (NCEs) provide insights into molecular recognition and also serve as leads for designing future new drugs. This review covers the syntheses of 21 NCEs marketed in 2009.

Publication types

Review

MeSH terms

Drug Approval*
Drug Design*
Humans
Molecular Targeted Therapy*
Pharmaceutical Preparations / chemical synthesis*

Substances

Pharmaceutical Preparations