Acylphloroglucinol and xanthones from Hypericum ellipticum

Kylie Manning; Elyse Petrunak; Michelle Lebo; Antonio González-Sarrías; Navindra P Seeram; Geneive E Henry

doi:10.1016/j.phytochem.2011.01.032

Acylphloroglucinol and xanthones from Hypericum ellipticum

Phytochemistry. 2011 May;72(7):662-7. doi: 10.1016/j.phytochem.2011.01.032. Epub 2011 Feb 19.

Authors

Kylie Manning¹, Elyse Petrunak, Michelle Lebo, Antonio González-Sarrías, Navindra P Seeram, Geneive E Henry

Affiliation

¹ Department of Chemistry, Susquehanna University, 514 University Avenue, Selinsgrove, PA 17870, USA.

PMID: 21338993
DOI: 10.1016/j.phytochem.2011.01.032

Abstract

An acylphloroglucinol, elliptophenone A, and two xanthones, elliptoxanthone A and elliptoxanthone B, were isolated from the aerial portions of Hypericum ellipticum together with three known xanthones, 1,3,7-trihydroxy-8-(3-methyl-2-butenyl)-9H-xanthen-9-one, 1,6-dihydroxy-4-methoxy-9H-xanthen-9-one, and 1,4,5-trihydroxy-9H-xanthen-9-one. Their structures were determined by spectroscopic analyses. The acylphloroglucinol and xanthones were evaluated for cytotoxicity using three human colon cancer cell lines cell lines (HT-29, HCT-116 and Caco-2) and a normal human colon cell line (CCD-18Co).

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Cell Line, Tumor
Humans
Hypericum / chemistry*
Inhibitory Concentration 50
Phloroglucinol / analogs & derivatives*
Phloroglucinol / chemistry
Phloroglucinol / isolation & purification
Phloroglucinol / pharmacology
Xanthones / chemistry*
Xanthones / isolation & purification
Xanthones / pharmacology*

Substances

Xanthones
elliptophenone A
xanthone
Phloroglucinol