Abstract
Malyngamide 3 (1) and cocosamides A (2) and B (3) were isolated from the lipophilic extract of a collection of Lyngbya majuscula from Cocos Lagoon, Guam. The planar structures of compounds 1-3 were determined by spectroscopic methods. The absolute configuration of 1 was determined by modified Mosher's method, NOESY data, and comparison with lyngbic acid (4). The absolute configurations of 2 and 3 were assigned by enantioselective HPLC analysis and comparison with the closely related compound pitipeptolide A (5). Compounds 1-3 showed weak cytotoxicity against MCF7 breast cancer and HT-29 colon cancer cells.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification*
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Antineoplastic Agents / pharmacology
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Cyanobacteria / chemistry*
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Depsipeptides / chemistry
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Depsipeptides / isolation & purification*
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Depsipeptides / pharmacology
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Drug Screening Assays, Antitumor
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Female
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Guam
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HT29 Cells
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Humans
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Lipopeptides / chemistry
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Lipopeptides / isolation & purification*
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Lipopeptides / pharmacology
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Marine Biology
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Molecular Structure
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Nuclear Magnetic Resonance, Biomolecular
Substances
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Antineoplastic Agents
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Depsipeptides
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Lipopeptides
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cocosamide A
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cocosamide B
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malyngamide 3