Abstract
Single-molecule sequencing enables DNA or RNA to be sequenced directly from biological samples, making it well-suited for diagnostic and clinical applications. Here we review the properties and applications of this rapidly evolving and promising technology.
Publication types
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Research Support, N.I.H., Extramural
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Review
MeSH terms
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Animals
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DNA / analysis*
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DNA / genetics
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DNA Primers / chemistry
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DNA Primers / genetics
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DNA-Directed DNA Polymerase / genetics
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DNA-Directed DNA Polymerase / metabolism
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Fluorescence
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Fluorescence Resonance Energy Transfer
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Genomics / instrumentation
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Genomics / methods*
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High-Throughput Nucleotide Sequencing / instrumentation
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High-Throughput Nucleotide Sequencing / methods*
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Humans
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Molecular Probes / chemistry
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Molecular Probes / metabolism
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Nanotechnology / instrumentation
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Nanotechnology / methods*
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Quantum Dots
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RNA / analysis*
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RNA / genetics
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Sequence Analysis, DNA / instrumentation
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Sequence Analysis, DNA / methods*
Substances
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DNA Primers
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Molecular Probes
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RNA
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DNA
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DNA-Directed DNA Polymerase