Formal synthesis of cortistatins

J Org Chem. 2011 Apr 15;76(8):2479-87. doi: 10.1021/jo102202t. Epub 2011 Mar 10.

Abstract

A unified strategy toward the asymmetric facile construction of the [6.7.6.5]oxapentacyclic skeleton of cortistatins is reported, featuring intramolecular Diels-Alder (IMDA), oxidative dearomatization, and an oxy-Michael addition reaction.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Angiogenesis Inhibitors / chemical synthesis*
  • Angiogenesis Inhibitors / therapeutic use
  • Animals
  • Aquatic Organisms / chemistry
  • Cyclization
  • Models, Molecular
  • Molecular Structure
  • Neovascularization, Pathologic / drug therapy
  • Neovascularization, Pathologic / prevention & control
  • Neovascularization, Physiologic / drug effects
  • Neuropeptides / chemical synthesis*
  • Neuropeptides / therapeutic use
  • Oxidation-Reduction
  • Porifera / chemistry
  • Stereoisomerism
  • Steroids / chemical synthesis*
  • Steroids / therapeutic use

Substances

  • Angiogenesis Inhibitors
  • Neuropeptides
  • Steroids
  • cortistatin