Abstract
A unified strategy toward the asymmetric facile construction of the [6.7.6.5]oxapentacyclic skeleton of cortistatins is reported, featuring intramolecular Diels-Alder (IMDA), oxidative dearomatization, and an oxy-Michael addition reaction.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Angiogenesis Inhibitors / chemical synthesis*
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Angiogenesis Inhibitors / therapeutic use
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Animals
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Aquatic Organisms / chemistry
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Cyclization
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Models, Molecular
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Molecular Structure
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Neovascularization, Pathologic / drug therapy
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Neovascularization, Pathologic / prevention & control
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Neovascularization, Physiologic / drug effects
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Neuropeptides / chemical synthesis*
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Neuropeptides / therapeutic use
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Oxidation-Reduction
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Porifera / chemistry
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Stereoisomerism
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Steroids / chemical synthesis*
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Steroids / therapeutic use
Substances
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Angiogenesis Inhibitors
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Neuropeptides
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Steroids
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cortistatin