Type 2 diabetes susceptibility single-nucleotide polymorphisms are not associated with polycystic ovary syndrome

Fertil Steril. 2011 Jun 30;95(8):2538-41.e1-6. doi: 10.1016/j.fertnstert.2011.02.050. Epub 2011 Mar 27.

Abstract

Two cohorts of women with polycystic ovary syndrome (PCOS), comprising 400 probands and affected sisters in 365 families and a case-control group including 395 women with PCOS and 171 healthy women with regular menstrual cycles, were studied to determine whether single-nucleotide polymorphisms (SNPs) identified as susceptibility loci in genomewide association studies of type 2 diabetes are also associated with PCOS. None of the 18 allelic variants in 10 genes previously shown to be associated with type 2 diabetes were found to be associated with PCOS, but some were associated with indices of beta cell function.

Publication types

  • Multicenter Study
  • Research Support, N.I.H., Extramural
  • Research Support, N.I.H., Intramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Case-Control Studies
  • Diabetes Mellitus, Type 2 / genetics*
  • Diabetes Mellitus, Type 2 / metabolism
  • Female
  • Gene Frequency
  • Genetic Predisposition to Disease
  • Genome-Wide Association Study
  • Haplotypes
  • Humans
  • Insulin-Secreting Cells / metabolism
  • Linkage Disequilibrium
  • Phenotype
  • Polycystic Ovary Syndrome / genetics*
  • Polycystic Ovary Syndrome / metabolism
  • Polymorphism, Single Nucleotide*
  • Risk Assessment
  • Risk Factors
  • United States

Grants and funding