Abstract
Two novel nano-cage compounds, 8 and 9, were prepared by self-assembly of the ruthenium complexes 4 and 5, and the tripodal donor 1. The cytotoxicity of 8 was found to be considerably stronger than that of cisplatin. The complex 8 inhibited tumor cell proliferation by interfering into regulatory pathways of the cell cycle via apoptosis.
© The Royal Society of Chemistry 2011
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
MeSH terms
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / pharmacology*
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Cell Line, Tumor
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Cell Proliferation / drug effects
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Cisplatin / chemistry*
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Crystallography, X-Ray
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Drug Screening Assays, Antitumor
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Humans
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Ligands
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Molecular Structure
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Organometallic Compounds / chemistry
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Organometallic Compounds / pharmacology*
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Ruthenium / chemistry*
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Structure-Activity Relationship
Substances
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Antineoplastic Agents
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Ligands
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Organometallic Compounds
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Ruthenium
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Cisplatin