Hexanuclear self-assembled arene-ruthenium nano-prismatic cages: potential anticancer agents

Chem Commun (Camb). 2011 May 14;47(18):5184-6. doi: 10.1039/c1cc10167f. Epub 2011 Mar 30.

Abstract

Two novel nano-cage compounds, 8 and 9, were prepared by self-assembly of the ruthenium complexes 4 and 5, and the tripodal donor 1. The cytotoxicity of 8 was found to be considerably stronger than that of cisplatin. The complex 8 inhibited tumor cell proliferation by interfering into regulatory pathways of the cell cycle via apoptosis.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Antineoplastic Agents / chemistry
  • Antineoplastic Agents / pharmacology*
  • Cell Line, Tumor
  • Cell Proliferation / drug effects
  • Cisplatin / chemistry*
  • Crystallography, X-Ray
  • Drug Screening Assays, Antitumor
  • Humans
  • Ligands
  • Molecular Structure
  • Organometallic Compounds / chemistry
  • Organometallic Compounds / pharmacology*
  • Ruthenium / chemistry*
  • Structure-Activity Relationship

Substances

  • Antineoplastic Agents
  • Ligands
  • Organometallic Compounds
  • Ruthenium
  • Cisplatin