Abstract
Sera from the elderly, but not young, inhibited markedly interleukin 2 (IL-2)-dependent proliferation of cloned T cells. Sera of aged humans contained high levels of triglyceride, cholesterol, very low density lipoproteins (VLDL) and low density lipoproteins (LDL). VLDL and LDL inhibited the proliferation in a dose-related manner. The inhibition correlated with levels of serum VLDL and LDL. These results suggest that lipoproteins may act as a regulator of IL-2-dependent proliferation and that disturbance of lipid and lipoprotein metabolism may be partially responsible for diminished immune responses in the elderly.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Adult
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Aged
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Aged, 80 and over
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Aging / blood
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Aging / immunology*
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Aging / metabolism
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Apolipoproteins / blood
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Apolipoproteins / immunology
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Apolipoproteins / pharmacology
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Cell Line
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Dose-Response Relationship, Immunologic
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Humans
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Interleukin-2 / immunology*
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Lipids / blood
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Lipids / immunology
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Lipids / pharmacology
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Lipoproteins, LDL / blood
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Lipoproteins, LDL / immunology
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Lipoproteins, LDL / pharmacology*
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Lipoproteins, VLDL / blood
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Lipoproteins, VLDL / immunology
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Lipoproteins, VLDL / pharmacology*
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Lymphocyte Activation / drug effects*
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T-Lymphocytes, Cytotoxic / drug effects*
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T-Lymphocytes, Helper-Inducer / drug effects*
Substances
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Apolipoproteins
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Interleukin-2
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Lipids
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Lipoproteins, LDL
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Lipoproteins, VLDL