Diagnostic radiography and adult acute myeloid leukaemia: an interview and medical chart review study

Br J Cancer. 2011 Apr 26;104(9):1482-6. doi: 10.1038/bjc.2011.114.

Abstract

Background: Aetiology of acute myeloid leukaemia (AML) is not well understood, perhaps because of its distinct subtypes. High-dose ionising radiation is a known risk factor, but less is known about risk from low-dose exposure such as from diagnostic radiography.

Methods: Subjects were 412 matched case-control pairs. Ten-year subject histories of diagnostic radiography were based on interview and medical records.

Results: There was no convincing association between AML risk and ionising radiation exposure from diagnostic imaging procedures, either for AML overall or for any AML subtype.

Conclusion: The association between diagnostic radiography and AML risk remains uncertain.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adult
  • Aged
  • California / epidemiology
  • Case-Control Studies
  • Female
  • Humans
  • Leukemia, Myeloid, Acute / epidemiology*
  • Leukemia, Myeloid, Acute / ethnology
  • Leukemia, Myeloid, Acute / etiology*
  • Leukemia, Myeloid, Acute / pathology
  • Male
  • Medical Records
  • Middle Aged
  • Radiography / adverse effects*
  • Retrospective Studies
  • Risk Assessment
  • Risk Factors
  • Surveys and Questionnaires