Biology of germ cell tumors

Hematol Oncol Clin North Am. 2011 Jun;25(3):457-71, vii. doi: 10.1016/j.hoc.2011.03.004. Epub 2011 Apr 13.

Abstract

Testicular cancer has been a model for a curable malignancy. The existence of an array of potential new therapies is the result of a prodigious effort in the researching and defining of the molecular components of the cancer phenotype and the subsequent rational design of agents to target candidate pathways. A better understanding of the molecular biology of cancer may also aid in guiding the most appropriate use of existing therapies, such as conventional chemotherapy.

Publication types

  • Review

MeSH terms

  • Antineoplastic Agents / therapeutic use
  • Chromosome Aberrations
  • Drug Resistance, Neoplasm / genetics*
  • Epigenesis, Genetic
  • Genetic Predisposition to Disease / genetics
  • Humans
  • Male
  • Molecular Biology*
  • Neoplasms, Germ Cell and Embryonal / drug therapy
  • Neoplasms, Germ Cell and Embryonal / genetics*
  • Testicular Neoplasms / drug therapy
  • Testicular Neoplasms / genetics*

Substances

  • Antineoplastic Agents