Abstract
We demonstrate a tumor mRNA-dependent drug carrier for controlled release of doxorubicin (Dox) and intracellular imaging based on gold nanoparticle-molecular beacon. Fluorescent Dox is released effectively and induces apoptosis in breast cancer cells but not in normal cells. Significantly, the release of Dox is correlated positively with the quantities of tumor mRNA, which is according to various stages of tumor progression, and so can decrease effectively side effects of Dox.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Base Sequence
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Breast Neoplasms / metabolism
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Breast Neoplasms / pathology*
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Cell Line, Tumor
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Delayed-Action Preparations
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Doxorubicin / chemistry
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Doxorubicin / metabolism
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Drug Carriers / chemistry*
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Gold / chemistry*
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Humans
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Intracellular Space / metabolism*
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Metal Nanoparticles / chemistry*
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Molecular Imaging / methods*
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Oligonucleotide Probes / genetics
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Oligonucleotide Probes / metabolism*
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RNA, Messenger / metabolism
Substances
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Delayed-Action Preparations
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Drug Carriers
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Oligonucleotide Probes
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RNA, Messenger
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Gold
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Doxorubicin