Absence of circulating antineutrophil cytoplasm antibodies (ANCA) in severe vasculitis associated with rheumatoid arthritis

Scand J Rheumatol. 1990;19(3):189-92. doi: 10.3109/03009749009095042.

Abstract

Sixteen patients with classical rheumatoid arthritis (RA) complicated by severe vasculitis were studied and compared with a matched control group of 17 RA patients without vasculitis. A control group of 24 patients with unrelated disease was also included. Neither antineutrophil cytoplasmic antibodies (C-ANCA) nor anti-myeloperoxidase (anti-MPO) were found. Granulocyte specific antinuclear antibodies ("GS-ANA") were found in a higher frequency in the vasculitis group (75%) than in the RA control group (41%), but the difference was not statistically significant. No patient in the control group without RA had "GS-ANA".

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Aged
  • Aged, 80 and over
  • Antibodies / analysis*
  • Antibody Specificity
  • Arthritis, Rheumatoid / complications*
  • Cytoplasm / immunology*
  • Enzyme-Linked Immunosorbent Assay
  • Female
  • Granulocytes / immunology
  • Humans
  • Male
  • Neutrophils / immunology*
  • Peroxidase / immunology
  • Vasculitis / etiology
  • Vasculitis / immunology*

Substances

  • Antibodies
  • Peroxidase