Cell polarity and migration: emerging role for the endosomal sorting machinery

Physiology (Bethesda). 2011 Jun;26(3):171-80. doi: 10.1152/physiol.00054.2010.

Abstract

The endosomal sorting complex required for transport (ESCRT) machinery has been implicated in the regulation of endosomal sorting, cell division, viral budding, autophagy, and cell signaling. Here, we review recent evidence that implicates ESCRTs in cell polarity and cell migration, and discuss the potential role of ESCRTs as tumor suppressors.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Animals
  • Cell Movement*
  • Cell Polarity*
  • Endosomal Sorting Complexes Required for Transport / metabolism*
  • Endosomes / metabolism*
  • Endosomes / pathology
  • Humans
  • Neoplasms / metabolism
  • Neoplasms / pathology
  • Signal Transduction*
  • Tumor Suppressor Proteins / metabolism

Substances

  • Endosomal Sorting Complexes Required for Transport
  • Tumor Suppressor Proteins