Conjugated polymer nanoparticles for small interfering RNA delivery

Chem Commun (Camb). 2011 Aug 7;47(29):8370-2. doi: 10.1039/c1cc10991j. Epub 2011 Jun 22.

Abstract

Loosely aggregated conjugated polymer nanoparticles (CPNs) were used as nontoxic and efficient small interfering RNA (siRNA) delivery vehicles with delivery visualization. A significant down regulation (94%) of a target gene was achieved by transfection of HeLa cells with the CPNs/siRNA complexes, supporting CPN as a promising siRNA delivery carrier.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Actins / antagonists & inhibitors
  • Actins / genetics
  • Actins / metabolism
  • HeLa Cells
  • Humans
  • Nanoparticles / chemistry*
  • Polymers / chemistry*
  • RNA Interference
  • RNA, Small Interfering / metabolism*

Substances

  • Actins
  • Polymers
  • RNA, Small Interfering