Administrative practices of health professionals and use of artesunate-amodiaquine by community members for treating uncomplicated malaria in southern Ghana: implications for artemisinin-based combination therapy deployment

Trop Med Int Health. 2011 Oct;16(10):1215-24. doi: 10.1111/j.1365-3156.2011.02833.x. Epub 2011 Jul 10.

Abstract

Objective: To investigate the use of artemisinin-based combination and monotherapy by community members and the administrative practices of health professionals in treating malaria in Ghana.

Method: This study is a community-based cross-sectional survey in 11 rural and urban areas in southern Ghana. Using the interviewer method, close-ended questionnaires were administered to community members. Similar questionnaires were also administered in health facilities, community pharmacies and licensed chemical shops.

Results: A total of 1085 individuals comprising 959 non-health professionals and 126 health professionals were interviewed. Fifty-seven per cent of the community members visit pharmacies/drug stores as the first point of call when they suspect malaria. According to the participating drug sellers, artemether-lumefantrine (AL) is the most prescribed/sold anti-malarial drug (59.2%), followed by dihydroartemisinin (35%), sulfadoxine-pyrimethamine (33.0%) and artesunate-amodiaquine (AS-AQ) (27.2%). The majority of customers who visit pharmacies or drug stores without prescription have their anti-malarial drug selected by the shop attendant; in situations like that, dihydroartemisinin and artesunate monotherapies are sold just as AS-AQ and AL. Chloroquine is still sold by some drug vendors, 5 years after its proscription.

Conclusion: Whereas the use of AS-AQ and AL are acceptable, the frequent use of dihydroartemisinin and artesunate monotherapy threatens the future of ACTs.

Publication types

  • Multicenter Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Amodiaquine / administration & dosage*
  • Antimalarials / administration & dosage*
  • Artemisinins / administration & dosage*
  • Child
  • Child, Preschool
  • Community-Based Participatory Research
  • Drug Combinations
  • Drug Resistance, Microbial
  • Drug Therapy, Combination
  • Drug Utilization / statistics & numerical data*
  • Drug Utilization / trends
  • Female
  • Ghana / epidemiology
  • Health Care Surveys
  • Humans
  • Infant
  • Male
  • Middle Aged
  • Nurses / statistics & numerical data*
  • Pharmacists / statistics & numerical data*
  • Pharmacy Technicians / statistics & numerical data
  • Physicians / statistics & numerical data*
  • Practice Patterns, Physicians' / statistics & numerical data
  • Rural Population / statistics & numerical data
  • Surveys and Questionnaires
  • Urban Population / statistics & numerical data

Substances

  • Antimalarials
  • Artemisinins
  • Drug Combinations
  • amodiaquine, artesunate drug combination
  • Amodiaquine
  • artenimol
  • artemisinin