Five-year progression-free survival in 577 patients operated on with laparoscopic radical prostatectomy for localized prostate cancer

Scand J Urol Nephrol. 2012 Feb;46(1):8-13. doi: 10.3109/00365599.2011.604790. Epub 2011 Aug 15.

Abstract

Objective: Laparoscopic radical prostatectomy (LRP) was introduced in the Department of Urology, Oslo University Hospital, in 2002. The aim of this study was to report mid-term oncology results and survival data.

Material and methods: From February 2002 to November 2007, 582 consecutive patients with localized prostate cancer underwent LRP. Data were collected prospectively into a database.

Results: Mean and median follow-up after LRP was 30.3 months (± 15.5) and 36.0 months (range 3-72). Five patients (1%) were lost during follow-up. Two patients died of prostate cancer during the study period and 10 patients died of other causes. The overall positive surgical margin (PSM) rate was 29% and decreased to 13% for the last 100 patients. The overall PSA progression-free survival (PFS) was 85% at 3 years and 73% at 5 years. Gleason score in the tumour specimen, pT stage and surgical margins were statistical significant independent predictors of biochemical PFS.

Conclusion: These oncology results and 5-year PFS data after LRP are in line with other reports.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adenocarcinoma / epidemiology
  • Adenocarcinoma / pathology
  • Adenocarcinoma / surgery*
  • Adult
  • Aged
  • Disease-Free Survival
  • Follow-Up Studies
  • Humans
  • Laparoscopy / methods*
  • Longitudinal Studies
  • Male
  • Middle Aged
  • Neoplasm Staging
  • Norway / epidemiology
  • Prospective Studies
  • Prostatectomy / methods*
  • Prostatic Neoplasms / epidemiology
  • Prostatic Neoplasms / pathology
  • Prostatic Neoplasms / surgery*
  • Retrospective Studies
  • Survival Rate
  • Treatment Outcome