Abstract
Certain carbohydrate-based biomarkers are known to correlate with cancer formation and progression. By targeting sialyl Lewis X, we have developed the first boronolectin-MS tag conjugate, which allows for MALDI-based imaging of cancer based on its cell surface carbohydrate.
This journal is © The Royal Society of Chemistry 2011
Publication types
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Research Support, N.I.H., Extramural
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Boron Compounds / chemical synthesis
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Boron Compounds / metabolism*
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Carcinoma, Renal Cell / metabolism
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Carcinoma, Renal Cell / pathology*
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Gene Expression Regulation, Neoplastic*
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Kidney Neoplasms / metabolism
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Kidney Neoplasms / pathology*
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Lewis X Antigen / metabolism*
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Molecular Imaging / methods*
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Monosaccharides / chemical synthesis
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Monosaccharides / metabolism*
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Sialyl Lewis X Antigen
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Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization / methods*
Substances
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Boron Compounds
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Lewis X Antigen
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Monosaccharides
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Sialyl Lewis X Antigen
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boronolectin