[Interaction of plasma selenium levels and D12S304 gene site in the pathogenesis of Kashin-Beck disease analyzed by multifactor dimensionality reduction software]

Wei Sheng Yan Jiu. 2011 Jul;40(4):472-3, 477.
[Article in Chinese]

Abstract

Objective: To explore the interaction of plasma selenium levels and D12S304 gene site in the pathogenesis of Kashin-Beck disease (KBD).

Methods: Case-control design was taken to compare the difference of plasma selenium levels and genotype of D12S304 between KBD patients and non-patients, and the interactions were analyzed by MDR software.

Results: Plasma selenium levels was lower in the case group than in the control group, while the D12S304 gene site was not different between the two groups, and no interaction between plasma selenium and genotype was observed.

Conclusion: There was no interaction between plasma selenium and genotype at D12S304. Enlarging sample size or selecting another gene site might be needed in exploring the gene-environment interactions in the pathogenesis of KBD.

Publication types

  • English Abstract
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Adolescent
  • Adult
  • Aged
  • Case-Control Studies
  • Child
  • China
  • Female
  • Gene-Environment Interaction
  • Genotype
  • Humans
  • Kashin-Beck Disease / blood
  • Kashin-Beck Disease / etiology*
  • Kashin-Beck Disease / genetics*
  • Male
  • Middle Aged
  • Multifactor Dimensionality Reduction*
  • Selenium / blood*
  • Selenium / deficiency
  • Software
  • Young Adult

Substances

  • Selenium