The promise and limitations of population exomics for human evolution studies

Jacob A Tennessen; Timothy D O'Connor; Michael J Bamshad; Joshua M Akey

doi:10.1186/gb-2011-12-9-127

The promise and limitations of population exomics for human evolution studies

Genome Biol. 2011 Sep 14;12(9):127. doi: 10.1186/gb-2011-12-9-127.

Authors

Jacob A Tennessen¹, Timothy D O'Connor, Michael J Bamshad, Joshua M Akey

Affiliation

¹ Department of Genome Sciences, University of Washington, 3720 15th Ave NE, Box 355065, Seattle, WA 98195-5065, USA.

Abstract

Exome sequencing is poised to yield substantial insights into human genetic variation and evolutionary history, but there are significant challenges to overcome before this becomes a reality.

Publication types

Research Support, N.I.H., Extramural

MeSH terms

Demography
Evolution, Molecular*
Exome*
Genetic Variation
Genetics, Population
Genome, Human
Genomics / methods*
Humans
Selection, Genetic
Sequence Analysis, DNA

Abstract

Publication types

MeSH terms

Grants and funding