The ability to vary femoral offset and neck angles in total hip arthroplasty increases the amount of flexibility in the mechanical reconstruction of the hip joint. The present study investigates the changes in strain pattern and bone-implant micromotion caused by increased femoral offset in combination with retroversion or reduced neck-shaft angle, made possible by a large experimental femoral head. A cementless femoral stem was inserted in 10 human cadaver femurs. Three femoral head configurations were tested: the standard situation, an increased offset combined with retroversion, and increased offset combined with reduced neck-shaft angle. The femurs were loaded in a hip simulator that was able to reproduce the conditions that correspond to one-legged stance and stair climbing. There was a statistically significant increase in strain for the experimental head at several strain gauge rosettes compared to the standard head. The largest significant increase in strain was 14.2 per cent on the anterior side of the femur. The largest mean total point motion was 44 microm in the distal coating area for the configuration with increased femoral offset and retroverted neck axis. The clinical relevance of the changes in strain distribution is uncertain. The femoral stem showed excellent initial stability for all test situations.