Design and synthesis of biotinylated DHMEQ for direct identification of its target NF-κB components

Tsuyoshi Saitoh; Masatoshi Takeiri; Yuko Gotoh; Yuichi Ishikawa; Kazuo Umezawa; Shigeru Nishiyama

doi:10.1016/j.bmcl.2011.08.122

Design and synthesis of biotinylated DHMEQ for direct identification of its target NF-κB components

Bioorg Med Chem Lett. 2011 Nov 1;21(21):6293-6. doi: 10.1016/j.bmcl.2011.08.122. Epub 2011 Sep 1.

Authors

Tsuyoshi Saitoh¹, Masatoshi Takeiri, Yuko Gotoh, Yuichi Ishikawa, Kazuo Umezawa, Shigeru Nishiyama

Affiliation

¹ Department of Chemistry, Faculty of Science and Technology, Keio University, Hiyoshi 3-14-1, Kohoku-ku, Yokohama 223-8522, Japan.

PMID: 21945203
DOI: 10.1016/j.bmcl.2011.08.122

Abstract

The design and synthesis of dehydroxymethylepoxyquinomicin (DHMEQ) derivatives were carried out to investigate the intracellular targets. The synthetic biotin probe exhibited membrane permeability and combined selectively with the target protein p65.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Benzamides / chemistry
Benzamides / pharmacology*
Biotin / chemistry*
Cyclohexanones / chemistry
Cyclohexanones / pharmacology*
Humans
NF-kappa B / drug effects*
Structure-Activity Relationship

Substances

Benzamides
Cyclohexanones
NF-kappa B
dehydroxymethylepoxyquinomicin
Biotin