Anaemia is of prognostic significance in patients with oesophageal adenocarcinoma

J R Coll Physicians Edinb. 2011 Sep;41(3):206-10. doi: 10.4997/JRCPE.2011.304.

Abstract

Anaemia is common in a wide range of malignancies and individual studies have demonstrated it to be an independent prognostic marker for survival in certain cancer types. The study population consisted of 171 patients: 77 anaemic and 94 non-anaemic. Sixty per cent of the study population had adenocarcinoma with 37% having squamous cell carcinoma. Late-stage disease occurred in 80% of individuals. There was no significant difference in survival times between the two groups (p=0.1), and after adjusting for confounding factors including age, sex, stage and physical status (p=0.8). Anaemic individuals with adenocarcinoma suffered a poorer survival probability compared to those with normal haemoglobon level (p=0.02). Anaemia is common at diagnosis in oesophageal cancer and was found to be a significant prognostic indicator of survival in adenocarcinoma, but not squamous cell carcinoma.

MeSH terms

  • Adenocarcinoma / blood
  • Adenocarcinoma / mortality*
  • Adult
  • Aged
  • Aged, 80 and over
  • Anemia* / blood
  • Anemia* / etiology
  • Carcinoma, Squamous Cell / blood
  • Carcinoma, Squamous Cell / mortality*
  • Disease Progression
  • Esophageal Neoplasms / blood
  • Esophageal Neoplasms / mortality*
  • Female
  • Hemoglobins / metabolism*
  • Humans
  • Male
  • Middle Aged
  • Neoplasm Staging
  • Prognosis

Substances

  • Hemoglobins