[Determination of supermolecular inclusion constants of hydroxylpropyl-beta-cylcodextrin with imperatorin and isoimperatorin by phase solubility method]

Zhong Yao Cai. 2011 Jun;34(6):965-7.
[Article in Chinese]

Abstract

Objective: To study the supermolecular interaction between different concentrations of hydroxypropyl-beta-cyclodextrin (HP-beta-CD) and imperatorin (IM) and isoimperatorin (ISO) using phase solubility analysis.

Methods: Different concentrations of hydroxypropyl-beta-cyclodextrin were prepared, added overdose of imperatorin or isoimperatorin, made a phase solubility diagram.

Results: The relationship of phase solubility was approximatively linear and the model of inclusion compound was AL and the inclusion ratio of IM, ISO versus HP-beta-CD was 1: 1. The inclusion constants were 214.4, 587.2 L/mol respectively.

Conclusions: Supermolecular inclusion of HP-beta-CD of imperatorin/isoimperatorin could evidently increase the solubility of imperatorin and isoimperatorin, the enhancing effect of isoimperatorin solubility is better than that of imperatorin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • 2-Hydroxypropyl-beta-cyclodextrin
  • Adsorption
  • Drug Compounding / methods
  • Drug Stability
  • Furocoumarins / chemistry*
  • Solubility
  • Solutions
  • Spectrophotometry, Ultraviolet / methods*
  • Water / chemistry
  • beta-Cyclodextrins / administration & dosage
  • beta-Cyclodextrins / chemistry*

Substances

  • Furocoumarins
  • Solutions
  • beta-Cyclodextrins
  • Water
  • isoimperatorin
  • 2-Hydroxypropyl-beta-cyclodextrin
  • imperatorin