Pilot study on a fast postoperative programming approach to subthalamic nucleus stimulation in Parkinson's disease

Neurol India. 2011 Sep-Oct;59(5):669-73. doi: 10.4103/0028-3886.86538.

Abstract

Objectives: T0 o evaluate the advantages and disadvantages of a fast post-operative screening method using deep brain stimulation (DBS) of the subthalamic nucleus (STN) in patients with Parkinson's disease.

Materials and methods: Twenty-four patients implanted with electrodes for STN-DBS were divided into two groups : Group I received traditional programming and Group II was treated with the fast method. The time required for programming in each group and the treatment effects were analyzed.

Results: Significant postoperative improvement of the Unified Parkinson's Disease Rating Scale III was achieved in the "off medication" and "on stimulation" condition in both the groups (Group I: 51.2% vs. Group II: 54.0%, P<0.05). The average time needed for programming, however, was significantly shorter in Group II as compared to Group I (P<0.05).

Conclusions: T0 he new fast method can significantly reduce the time required to find a preliminary effective STN-DBS protocol in the early postoperative phase without sacrificing clinical efficacy.

Publication types

  • Clinical Trial

MeSH terms

  • Aged
  • Algorithms
  • Deep Brain Stimulation / methods*
  • Electrodes, Implanted
  • Female
  • Humans
  • Male
  • Middle Aged
  • Parkinson Disease / therapy*
  • Pilot Projects
  • Postoperative Period
  • Severity of Illness Index
  • Subthalamic Nucleus / physiology*
  • Time Factors
  • Treatment Outcome*