Phenolic glycosides from sugar maple (Acer saccharum) bark

Tao Yuan; Chunpeng Wan; Antonio González-Sarrías; Vamsikrishna Kandhi; Nadja B Cech; Navindra P Seeram

doi:10.1021/np200678n

Phenolic glycosides from sugar maple (Acer saccharum) bark

J Nat Prod. 2011 Nov 28;74(11):2472-6. doi: 10.1021/np200678n. Epub 2011 Oct 27.

Authors

Tao Yuan¹, Chunpeng Wan, Antonio González-Sarrías, Vamsikrishna Kandhi, Nadja B Cech, Navindra P Seeram

Affiliation

¹ Bioactive Botanical Research Laboratory, Department of Biomedical and Pharmaceutical Sciences, College of Pharmacy, University of Rhode Island, Kingston, Rhode Island 02881, USA.

PMID: 22032697
DOI: 10.1021/np200678n

Abstract

Four new phenolic glycosides, saccharumosides A-D (1-4), along with eight known phenolic glycosides, were isolated from the bark of sugar maple (Acer saccharum). The structures of 1-4 were elucidated on the basis of spectroscopic data analysis. All compounds isolated were evaluated for cytotoxicity effects against human colon tumorigenic (HCT-116 and Caco-2) and nontumorigenic (CCD-18Co) cell lines.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Acer / chemistry*
Antineoplastic Agents, Phytogenic / chemistry
Antineoplastic Agents, Phytogenic / isolation & purification*
Antineoplastic Agents, Phytogenic / pharmacology
Canada
Drug Screening Assays, Antitumor
Glycosides / chemistry
Glycosides / isolation & purification*
Glycosides / pharmacology
HCT116 Cells
Humans
Molecular Structure
Nuclear Magnetic Resonance, Biomolecular
Phenols / chemistry
Phenols / isolation & purification*
Phenols / pharmacology
Plant Bark / chemistry

Substances

Antineoplastic Agents, Phytogenic
Glycosides
Phenols