Solid-phase synthesis of arginine-based double-tailed cationic lipopeptides: potent nucleic acid carriers

Chem Commun (Camb). 2011 Dec 28;47(48):12774-6. doi: 10.1039/c1cc15805h. Epub 2011 Nov 1.

Abstract

Herein we report a highly-efficient solid-phase strategy for the modular synthesis of 63 double-tailed lipid-peptide conjugates and their application in DNA delivery.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Arginine / chemistry*
  • DNA / chemistry
  • DNA / metabolism*
  • HeLa Cells
  • Humans
  • Lipopeptides / chemical synthesis*
  • Lipopeptides / chemistry*
  • Solid-Phase Synthesis Techniques*
  • Transfection

Substances

  • Lipopeptides
  • DNA
  • Arginine