This cross-sectional, secondary analysis study utilizes data from a prior study of intergenerational substance use among Latina women (n = 316). We explored the influence of substance use frequency and type, as well as cultural and socioeconomic factors on attributions about addiction among a predominantly immigrant sample of Latina women. Women who were less proficient in English (an indicator of adoption of the receiving culture in the acculturation process) and more proficient in Spanish (an indicator of heritage-culture retention) endorsed more spiritual model attributions than women who were more proficient in English and less proficient in Spanish. Women were more proficient in Spanish more frequently endorsed the disease attribution model. Alcohol, marijuana use and non-medical sedative use were linked with spiritual, moral /character and disease attribution models respectively. Participants reporting higher education levels indicated less agreement with the moral/character model of addiction. Implications for culturally tailored social work interventions for Latina women are discussed.