Olanzapine-associated myoclonus

Epilepsy Res. 2012 Feb;98(2-3):247-50. doi: 10.1016/j.eplepsyres.2011.07.020. Epub 2011 Dec 21.

Abstract

Olanzapine is an atypical antipsychotic drug that infrequently has been reported to cause seizures and myoclonus despite a small proconvulsant risk. This is the first report of generalized myoclonus induced in a patient who had been maintained on low dose olanzapine for over seven years without any change in her dose. Olanzapine was discontinued, and the myoclonic jerks completely resolved within 48 h.

Publication types

  • Case Reports

MeSH terms

  • Aged
  • Alzheimer Disease / complications
  • Alzheimer Disease / drug therapy
  • Antipsychotic Agents / adverse effects*
  • Benzodiazepines / adverse effects*
  • Electroencephalography
  • Female
  • Humans
  • Myoclonus / chemically induced*
  • Myoclonus / physiopathology
  • Olanzapine
  • Psychotic Disorders / complications
  • Psychotic Disorders / drug therapy

Substances

  • Antipsychotic Agents
  • Benzodiazepines
  • Olanzapine