Three different LDL apheresis columns efficiently and equally reduce lipoprotein(a) concentrations in patients with familial hypercholesterolemia and small apolipoprotein(a) particles

Transfus Apher Sci. 2012 Feb;46(1):73-6. doi: 10.1016/j.transci.2011.11.016. Epub 2011 Dec 27.

Abstract

Introduction: High levels of lipoprotein(a) [Lp(a)] and apolipoprotein(a) [apo(a)] are associated with cardiovascular disease. In this study we determined apo(a) particle size and compared the Lp(a) reducing efficacy of three different LDL apheresis columns; DL-75, LA-15 and EC-50W in patients with familial hypercholesterolemia (FH).

Results: Average Lp(a) concentration was reduced by 70%, 74% and 75% (all p<0.0001) for DL-75, LA-15 and EC-50W, respectively. No significant changes in the relative proportion of the isoforms of 14 and 32K 4 domains were observed after apheresis.

Conclusion: Three different LDL apheresis columns reduced Lp(a) efficiently with preserved ratio between apo(a) isoforms.

Publication types

  • Clinical Trial
  • Comparative Study
  • Research Support, Non-U.S. Gov't

MeSH terms

  • Apolipoproteins A*
  • Blood Component Removal / instrumentation*
  • Blood Component Removal / methods
  • Cardiovascular Diseases / blood
  • Cardiovascular Diseases / therapy
  • Female
  • Humans
  • Hypercholesterolemia / blood
  • Hypercholesterolemia / therapy*
  • Lipid Metabolism, Inborn Errors / blood
  • Lipid Metabolism, Inborn Errors / therapy*
  • Lipoprotein(a)*
  • Male

Substances

  • Apolipoproteins A
  • Lipoprotein(a)