Abstract
Extraskeletal osteosarcoma (ESOS) is a rare malignancy, usually arising in older adults. We were unable to find reports of children or adolescents affected by an ESOS of the breast. Here, we present the case of a high-grade osteosarcoma arising in the breast of a 16-year-old girl. The tumor was treated with breast-conserving resections and adjuvant multiagent chemotherapy, based on a regimen of doxorubicin, high-dose methotrexate, cisplatin, and ifosfamide. At last follow-up, the patient was in first complete remission, 29 months after initial diagnosis.
MeSH terms
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Adolescent
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Antineoplastic Combined Chemotherapy Protocols / therapeutic use*
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Bone Neoplasms / drug therapy
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Bone Neoplasms / secondary*
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Breast Neoplasms / drug therapy
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Breast Neoplasms / pathology*
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Chemotherapy, Adjuvant
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Chondroblastoma / drug therapy
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Chondroblastoma / secondary*
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Cisplatin / administration & dosage
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Doxorubicin / administration & dosage
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Female
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Humans
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Ifosfamide / administration & dosage
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Methotrexate / administration & dosage
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Neoplasm Grading
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Osteosarcoma / drug therapy
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Osteosarcoma / secondary*
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Treatment Outcome
Substances
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Doxorubicin
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Cisplatin
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Ifosfamide
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Methotrexate