Galantamine attenuates reinstatement of cue-induced methamphetamine-seeking behavior in mice

Addict Biol. 2014 Jan;19(1):1-4. doi: 10.1111/j.1369-1600.2011.00425.x. Epub 2012 Jan 19.

Abstract

Methamphetamine (METH) dependence is becoming a serious socioeconomic health problem worldwide. The enhancement of the cholinergic nervous system is expected to greatly alleviate drug dependence. We investigated the effect of galantamine on the reinstatement of cue-induced METH-seeking behavior using a self-administration experiment. Treatment with galantamine (1 mg/kg, p.o.) 30 minutes before exposure to the cues suppressed the reinstatement of METH-seeking behavior. However, galantamine did not affect the cue-induced reinstatement of food-seeking behavior or locomotor activity. These results suggest that galantamine may be a candidate drug for treating relapses of METH-seeking behavior.

Keywords: Food-seeking behavior; galantamine; methamphetamine; methamphetamine-seeking behavior; reinstatement; self-administration.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Amphetamine-Related Disorders / prevention & control
  • Analysis of Variance
  • Animals
  • Appetitive Behavior / drug effects
  • Central Nervous System Stimulants / administration & dosage*
  • Cholinesterase Inhibitors / administration & dosage
  • Cholinesterase Inhibitors / pharmacology*
  • Conditioning, Operant
  • Cues
  • Dose-Response Relationship, Drug
  • Drug-Seeking Behavior / drug effects*
  • Galantamine / administration & dosage
  • Galantamine / pharmacology*
  • Humans
  • Locomotion / drug effects
  • Methamphetamine / administration & dosage*
  • Mice
  • Nucleus Accumbens / drug effects
  • Secondary Prevention
  • Self Administration / statistics & numerical data

Substances

  • Central Nervous System Stimulants
  • Cholinesterase Inhibitors
  • Galantamine
  • Methamphetamine