The porous borders of the protein world

Structure. 2012 Feb 8;20(2):199-200. doi: 10.1016/j.str.2012.01.015.

Abstract

Fold switching may play a role in the evolution of new protein folds and functions. He et al., in this issue of Structure, use protein design to illustrate that the same drastic change in a protein fold can occur via multiple different mutational pathways.

Publication types

  • Comment

MeSH terms

  • Amino Acid Substitution*
  • Bacterial Proteins / chemistry*
  • Peptide Fragments / chemistry*
  • Protein Folding*

Substances

  • Bacterial Proteins
  • IgG Fc-binding protein, Streptococcus
  • Peptide Fragments