Abstract
In our previous study, we found that acute anterior uveitis (AAU) could be induced in wild-type mice (C3H/HeN), but it could not be induced in TLR4 gene-deficient mice (C3H/HeJ), we concluded that the translocation of transcription factor nuclear factor-κB (NF-κB) may play an important role. In this study, we examined the concentration of different cytokines in the aqueous humor of C3H/HeN mice and C3H/HeJ mice with the aim of exploring the role of different cytokines in the lipopolysaccharide (LPS) and TLR4-mediated signal transduction in the development of AAU.
Keywords:
Anterior Uveitis; Cytokine; Toll-like receptor 4; aqueous humor; cytometric bead array technology.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Aqueous Humor / chemistry
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Aqueous Humor / metabolism*
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Endotoxins
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Interferon-gamma / analysis
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Interferon-gamma / metabolism
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Interleukin-1 / analysis
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Interleukin-1 / metabolism
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Interleukin-10 / analysis
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Interleukin-10 / metabolism
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Interleukin-6 / analysis
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Interleukin-6 / metabolism
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Lipopolysaccharides
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Male
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Mice
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Mice, Inbred C3H
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Signal Transduction
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Toll-Like Receptor 4 / physiology*
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Tumor Necrosis Factor-alpha / analysis
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Tumor Necrosis Factor-alpha / metabolism
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Uveitis / metabolism*
Substances
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Endotoxins
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Interleukin-1
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Interleukin-6
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Lipopolysaccharides
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Toll-Like Receptor 4
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Tumor Necrosis Factor-alpha
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Interleukin-10
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Interferon-gamma