Reduction of toxicity and increase of antitumor effect of adriamycin by N-acyl dehydroalanines, a new family of free radical scavengers

Adv Exp Med Biol. 1990:264:339-44. doi: 10.1007/978-1-4684-5730-8_52.
No abstract available

MeSH terms

  • Alanine / analogs & derivatives*
  • Alanine / pharmacology
  • Animals
  • Doxorubicin / pharmacology
  • Doxorubicin / toxicity*
  • Female
  • Free Radical Scavengers*
  • In Vitro Techniques
  • Leukemia L1210 / drug therapy
  • Leukemia L1210 / physiopathology
  • Leukemia, Experimental / drug therapy
  • Membrane Lipids / metabolism
  • Mice
  • Mice, Inbred Strains
  • Microsomes, Liver / drug effects
  • Oxidation-Reduction
  • Radiation-Protective Agents / pharmacology*
  • Rats

Substances

  • Free Radical Scavengers
  • Membrane Lipids
  • Radiation-Protective Agents
  • AD 20
  • Doxorubicin
  • Alanine