Prediction of cytogenetic abnormalities with gene expression profiles

Blood. 2012 May 24;119(21):e148-50. doi: 10.1182/blood-2011-10-388702. Epub 2012 Apr 10.

Abstract

Cytogenetic abnormalities are important clinical parameters in various types of cancer, including multiple myeloma. We developed a model to predict cytogenetic abnormalities in patients with multiple myeloma using gene expression profiling and validated it by different cytogenetic techniques. The model has an accuracy rate up to 0.89. These results provide proof of concept for the hypothesis that gene expression profiling is a superior genomic method for clinical molecular diagnosis and/or prognosis.

Publication types

  • Research Support, N.I.H., Extramural
  • Validation Study

MeSH terms

  • Biopsy, Needle
  • Bone Marrow / metabolism
  • Bone Marrow / pathology
  • Case-Control Studies
  • Chromosome Aberrations*
  • Comparative Genomic Hybridization
  • Cytogenetic Analysis / methods*
  • Female
  • Gene Expression Profiling* / methods
  • Humans
  • Male
  • Microarray Analysis / methods
  • Models, Statistical
  • Multiple Myeloma / diagnosis*
  • Multiple Myeloma / genetics*
  • Multiple Myeloma / mortality
  • Multiple Myeloma / pathology
  • Prognosis
  • Sensitivity and Specificity