CO2 gas induced drug release from pH-sensitive liposome to circumvent doxorubicin resistant cells

Chem Commun (Camb). 2012 May 18;48(40):4869-71. doi: 10.1039/c2cc31697h. Epub 2012 Apr 12.

Abstract

A novel pH-sensitive liposome encapsulating doxorubicin was prepared by a NH(4)HCO(3) gradient method. The liposomes were able to release the drug at pH 5.0 by the production of CO(2) gas. More importantly, the drug-loaded liposome effectively circumvented the breast cancer cells resistant to doxorubicin.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Carbon Dioxide / metabolism*
  • Cell Line, Tumor
  • Cell Survival / drug effects*
  • Doxorubicin / chemistry
  • Doxorubicin / pharmacology*
  • Drug Resistance, Neoplasm
  • Gases / metabolism
  • Humans
  • Hydrogen-Ion Concentration
  • Liposomes / chemistry*

Substances

  • Gases
  • Liposomes
  • Carbon Dioxide
  • Doxorubicin