Association study of copy number variants with brain volume in schizophrenia patients and healthy controls

Afke Terwisscha van Scheltinga; Steven Bakker; Neeltje van Haren; Jacobine Buizer-Voskamp; Heleen Boos; Jacob Vorstman; Wiepke Cahn; Hilleke Hulshoff Pol; Roel Ophoff; René Kahn

doi:10.1016/j.psychres.2012.04.007

Association study of copy number variants with brain volume in schizophrenia patients and healthy controls

Psychiatry Res. 2012 Dec 30;200(2-3):1011-3. doi: 10.1016/j.psychres.2012.04.007. Epub 2012 May 1.

Authors

Afke Terwisscha van Scheltinga¹, Steven Bakker, Neeltje van Haren, Jacobine Buizer-Voskamp, Heleen Boos, Jacob Vorstman, Wiepke Cahn, Hilleke Hulshoff Pol, Roel Ophoff, René Kahn

Affiliation

¹ Department of Psychiatry, Rudolf Magnus Institute of Neuroscience, University Medical Centre Utrecht, Huispostnummer A00.241, Heidelberglaan 100, 3584 CX, Utrecht, the Netherlands. aterwiss@umcutrecht.nl

PMID: 22551941
DOI: 10.1016/j.psychres.2012.04.007

Abstract

Schizophrenia patients have more copy number variations (CNVs) than healthy controls, and reduced brain volumes. Although this could suggest a causal relationship, we found no association between global CNV burden and three brain volume measures (on a MRI scan) in a sample of 173 schizophrenia patients and 176 healthy controls.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adult
Brain / pathology*
DNA Copy Number Variations*
Female
Genetic Predisposition to Disease
Genotype
Humans
Magnetic Resonance Imaging
Male
Organ Size / genetics
Schizophrenia / genetics*
Schizophrenia / pathology*