Abstract
The total synthesis of (±)-sorocenol B has been accomplished featuring key steps including silver nanoparticle (AgNP)-catalyzed Diels-Alder cycloaddition and late-stage Pd(II)-catalyzed oxidative cyclization. The synthetic natural product exhibited low micromolar cytotoxic activity against a number of human cancer cell lines.
Publication types
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Research Support, N.I.H., Extramural
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Research Support, Non-U.S. Gov't
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Research Support, U.S. Gov't, Non-P.H.S.
MeSH terms
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Biological Products / chemical synthesis*
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Biological Products / chemistry
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Catalysis
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Cyclization
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Cycloaddition Reaction
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Heterocyclic Compounds, 4 or More Rings / chemistry
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Humans
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Metal Nanoparticles / chemistry*
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Molecular Structure
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Moraceae / chemistry
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Oxidation-Reduction
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Silver / chemistry*
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Stereoisomerism
Substances
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Biological Products
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Heterocyclic Compounds, 4 or More Rings
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sorocenol B
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Silver