Marginal additive hazards model for case-cohort studies with multiple disease outcomes: an application to the Atherosclerosis Risk in Communities (ARIC) study

Biostatistics. 2013 Jan;14(1):28-41. doi: 10.1093/biostatistics/kxs025. Epub 2012 Jul 23.

Abstract

In the case-cohort studies conducted within the Atherosclerosis Risk in Communities (ARIC) study, it is of interest to assess and compare the effect of high-sensitivity C-reactive protein (hs-CRP) on the increased risks of incident coronary heart disease and incident ischemic stroke. Empirical cumulative hazards functions for different levels of hs-CRP reveal an additive structure for the risks for each disease outcome. Additionally, we are interested in estimating the difference in the risk for the different hs-CRP groups. Motivated by this, we consider fitting marginal additive hazards regression models for case-cohort studies with multiple disease outcomes. We consider a weighted estimating equations approach for the estimation of model parameters. The asymptotic properties of the proposed estimators are derived and their finite-sample properties are assessed via simulation studies. The proposed method is applied to analyze the ARIC Study.

Publication types

  • Research Support, N.I.H., Extramural

MeSH terms

  • Atherosclerosis / epidemiology*
  • Atherosclerosis / metabolism
  • Atherosclerosis / pathology
  • C-Reactive Protein / analysis
  • C-Reactive Protein / metabolism*
  • Case-Control Studies
  • Cohort Studies
  • Computer Simulation
  • Coronary Artery Disease / epidemiology*
  • Coronary Artery Disease / metabolism
  • Coronary Artery Disease / pathology
  • Coronary Disease / epidemiology*
  • Coronary Disease / metabolism
  • Coronary Disease / pathology
  • Humans
  • Proportional Hazards Models*
  • Risk

Substances

  • C-Reactive Protein