How can proteins enter the interior of a MOF? Investigation of cytochrome c translocation into a MOF consisting of mesoporous cages with microporous windows

Yao Chen; Vasiliki Lykourinou; Carissa Vetromile; Tran Hoang; Li-June Ming; Randy W Larsen; Shengqian Ma

doi:10.1021/ja305144x

How can proteins enter the interior of a MOF? Investigation of cytochrome c translocation into a MOF consisting of mesoporous cages with microporous windows

J Am Chem Soc. 2012 Aug 15;134(32):13188-91. doi: 10.1021/ja305144x. Epub 2012 Aug 6.

Authors

Yao Chen¹, Vasiliki Lykourinou, Carissa Vetromile, Tran Hoang, Li-June Ming, Randy W Larsen, Shengqian Ma

Affiliation

¹ Department of Chemistry, University of South Florida, 4202 East Fowler Avenue, Tampa, Florida 33620, USA.

PMID: 22862180
DOI: 10.1021/ja305144x

Abstract

It has been demonstrated for the first time that the heme protein cytochrome c (Cyt c) can enter the interior of a MOF despite the larger molecular dimension of the protein relative to the access pore sizes. Mechanistic studies suggest that the Cyt c molecules must undergo a significant conformational change during translocation into the MOF interior through the relatively small nanopores.

Publication types

Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

Cytochromes c / metabolism*
Models, Molecular
Molecular Conformation
Organometallic Compounds / chemistry
Organometallic Compounds / metabolism*
Porosity
Protein Transport
Proteins / metabolism*
Spectrometry, Fluorescence

Substances

Organometallic Compounds
Proteins
Cytochromes c