Molecular logic gates for DNA analysis: detection of rifampin resistance in M. tuberculosis DNA

Angew Chem Int Ed Engl. 2012 Sep 3;51(36):9075-7. doi: 10.1002/anie.201203708. Epub 2012 Aug 9.

Abstract

Elementary, Dr. Watson! A combination of YES and OR logic gates was applied to differentiate between DNA sequences of wild-type and rifampin-resistant (Rif(r)) Mycobacterium tuberculosis (Mtb) in a multiplex real-time fluorescent assay.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Antibiotics, Antitubercular / pharmacology*
  • DNA, Bacterial / analysis*
  • Drug Resistance, Bacterial / drug effects
  • Mycobacterium tuberculosis / drug effects
  • Mycobacterium tuberculosis / genetics*
  • Mycobacterium tuberculosis / isolation & purification
  • Polymerase Chain Reaction
  • Rifampin / pharmacology*
  • Spectrometry, Fluorescence

Substances

  • Antibiotics, Antitubercular
  • DNA, Bacterial
  • Rifampin