Archaeal orc1/cdc6 proteins

Subcell Biochem. 2012:62:59-69. doi: 10.1007/978-94-007-4572-8_4.

Abstract

The initiation of DNA replication in most archaeal genomes is mediated by proteins related to eukaryotic Orc1 and Cdc6. Archaeal replication origins have been mapped and their interactions with Orc1/Cdc6 proteins have been characterized at the biochemical level. Structural and biophysical studies have revealed the basic rules of sequence recognition by archaeal initiators.

Publication types

  • Research Support, Non-U.S. Gov't
  • Review

MeSH terms

  • Archaea / physiology*
  • Archaeal Proteins* / genetics
  • Archaeal Proteins* / metabolism
  • Cell Cycle Proteins* / genetics
  • Cell Cycle Proteins* / metabolism
  • DNA Replication / physiology*
  • DNA, Archaeal* / biosynthesis
  • DNA, Archaeal* / genetics
  • DNA-Binding Proteins* / genetics
  • DNA-Binding Proteins* / metabolism

Substances

  • Archaeal Proteins
  • Cell Cycle Proteins
  • DNA, Archaeal
  • DNA-Binding Proteins