Abstract
Macrophage scavenger receptors appear to play a major role in the clearance of oxidized phospholipid (OxPL) products. Discrete peptide-phospholipid conjugates with the phosphatidylcholine headgroup have been shown to exhibit binding affinity for these receptors. We report the preparation of a water-soluble, stable peptide-phospholipid conjugate (9) that possesses the necessary physical properties to enable more detailed study of the role(s) of OxPL in metabolic disease.
Publication types
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Research Support, N.I.H., Extramural
MeSH terms
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Animals
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Antibodies, Monoclonal / metabolism
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Biomimetic Materials / chemical synthesis*
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Biomimetic Materials / chemistry
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Biomimetic Materials / metabolism*
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CD36 Antigens / metabolism*
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Chemistry Techniques, Synthetic
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Drug Design*
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Drug Stability
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Humans
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Mice
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Oxidation-Reduction
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Phospholipid Ethers / chemistry*
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Phospholipid Ethers / metabolism
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Protein Binding
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Solubility
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Substrate Specificity
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Water / chemistry
Substances
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1-palmitoyl-2-(5-oxovaleroyl)-sn-glycero-3-phosphorylcholine
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Antibodies, Monoclonal
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CD36 Antigens
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Phospholipid Ethers
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Water