Real-time monitoring biomarker expression of carcinoma cells by surface plasmon resonance biosensors

Chem Commun (Camb). 2012 Oct 28;48(84):10389-91. doi: 10.1039/c2cc34853e. Epub 2012 Sep 6.

Abstract

A novel surface plasmon resonance (SPR) biosensor which is capable of monitoring proteomic biomarker secretion from living cells is reported here. Vascular endothelial growth factor (VEGF) secretion from living SKOV-3 ovarian cancer cells was measured for concept demonstration.

Publication types

  • Research Support, N.I.H., Extramural
  • Research Support, Non-U.S. Gov't
  • Research Support, U.S. Gov't, Non-P.H.S.

MeSH terms

  • Biomarkers / analysis
  • Biomarkers / metabolism
  • Carcinoma / chemistry*
  • Carcinoma / metabolism
  • Carcinoma / pathology
  • Cell Line, Tumor
  • Female
  • Humans
  • Ovarian Neoplasms / chemistry*
  • Ovarian Neoplasms / metabolism
  • Ovarian Neoplasms / pathology
  • Surface Plasmon Resonance*
  • Vascular Endothelial Growth Factor A / analysis*
  • Vascular Endothelial Growth Factor A / metabolism

Substances

  • Biomarkers
  • Vascular Endothelial Growth Factor A