Incorporation of penicillin-producing fungi into living materials to provide chemically active and antibiotic-releasing surfaces

Angew Chem Int Ed Engl. 2012 Nov 5;51(45):11293-6. doi: 10.1002/anie.201204337. Epub 2012 Oct 9.

Abstract

Living materials: artificial biological niches are loaded with the penicillin-producing mold Penicillium chrysogenum. This living material consumes food through a nanoporous top layer and releases the antibiotic on-site. No reloading of the active compound is needed. Gram-positive bacteria were efficiently killed if nearby, whereas Gram-negative bacteria (control experiment, not sensitive to penicillin) were not affected.

Publication types

  • Research Support, Non-U.S. Gov't

MeSH terms

  • Biomimetic Materials / metabolism
  • Fungi / genetics
  • Fungi / growth & development*
  • Fungi / metabolism*
  • Microbial Sensitivity Tests
  • Mycology / methods
  • Penicillins / biosynthesis*
  • Penicillins / pharmacology
  • Penicillium / growth & development
  • Penicillium / metabolism*

Substances

  • Penicillins