Long-term outcome of palliative treatment with self-expanding metal stents for malignant obstructions of the GI tract

Scand J Gastroenterol. 2012 Dec;47(12):1505-14. doi: 10.3109/00365521.2012.711854. Epub 2012 Oct 10.

Abstract

Background: Self-expanding metal stents (SEMS) are commonly used in the palliative treatment of malignant gastrointestinal (GI) obstructions with favorable short-term outcome. Data on long-term outcome are scarce, however.

Aim: To evaluate long-term outcome after palliative stent treatment of malignant GI obstruction.

Method: Between October 2006 and April 2008, nine Norwegian hospitals included patients treated with SEMS for malignant esophageal, gastroduodenal, biliary, and colonic obstructions. Patients were followed for at least 6 months with respect to stent patency, reinterventions, and readmissions.

Results: Stent placement was technically successful in 229 of 231 (99%) and clinically successful after 1 week in 220 of 229 (96%) patients. Long-term follow-up was available for 219 patients. Of those, 72 (33%) needed reinterventions. Stent occlusions or migrations (92%) were the most common reasons. Esophageal stents required reinterventions most frequently (41%), and had a significantly (p = 0.02) shorter patency (median 152 days) compared to other locations (gastroduodenal, 256 days; colon, 276 days; biliary, 460 days). Eighty percent of reinterventions were repeated endoscopic procedures that successfully restored patency. Readmissions were required for 156 (72%) patients. Progression of the underlying cancer was the most common reason, whereas 24% were readmitted due to stent complications.

Conclusions: Long-term outcome after palliative treatment with SEMS for malignant GI and biliary obstruction shows that 70% had a patent stent until death, and that most reobstructions could be solved endoscopically. Hospital readmissions were mainly related to progression of the underlying cancer disease.

MeSH terms

  • Adult
  • Aged
  • Aged, 80 and over
  • Cholestasis / etiology
  • Cholestasis / surgery*
  • Disease Progression
  • Endoscopy, Gastrointestinal
  • Esophageal Stenosis / etiology
  • Esophageal Stenosis / surgery*
  • Female
  • Follow-Up Studies
  • Humans
  • Intestinal Obstruction / etiology
  • Intestinal Obstruction / surgery*
  • Kaplan-Meier Estimate
  • Male
  • Middle Aged
  • Neoplasms / complications*
  • Neoplasms / surgery
  • Norway
  • Palliative Care*
  • Patient Readmission
  • Prosthesis Failure
  • Reoperation
  • Statistics, Nonparametric
  • Stents*
  • Time Factors