The effects of airway care procedures on intracranial dynamics were studied in 12 patients with intracranial lesions. The patients had controlled ventilation and were treated according to a standardized protocol with endotracheal suction and bag squeezing. Intracranial, arterial blood and airway pressures were recorded and cerebral perfusion pressure was calculated. Both methods used for airway care elicited marked changes in intracranial, arterial blood and cerebral perfusion pressures during the treatment session. However, within 1 min after termination of the procedure the different pressure levels returned to pretreatment values except for the intracranial and arterial blood pressure in endotracheal suction. Cerebral perfusion pressure, calculated at different time intervals: 1, 5 and 15 min after the treatment, showed only minor deviations from values before treatment. The mean values varied from 70 to 90 mmHg (9.3 to 12.0 kPa) and the lower limit of the 99% confidence interval of the means was never below 55 mmHg (7.3 kPa). At times complementary administration of sedatives during endotracheal suction was found to induce a drop in arterial blood pressure and cerebral perfusion pressure. In conclusion, patients with severe brain injuries treated on mechanical ventilation are exposed to equal risks when using bag squeezing for airway care as when using traditional endotracheal suction. Regardless of the method used, patients should be adequately sedated before starting the procedure in order to reduce the risk of adverse effects.