In 2011, through regular surveillance of more than 100 English-language research journals, a group of seven clinicians identified approximately 250 studies with the potential to improve the practice of primary care physicians and the outcomes of patients (designated as POEMs [patient-oriented evidence that matters]). Using a validated tool, Canadian primary care physicians have been rating the relevance of each POEM as they receive it in their e-mail. This article summarizes 20 of the most relevant, practice-changing POEMs from 2011 as determined by these raters. We believe this approach has greater relevance and validity than a subjective list of studies selected by experts or editors, because it is based on the actual ratings of practicing primary care physicians. These POEMs address topics that include how to best measure blood pressure, the lack of benefit of intensive glucose control, quantification of the benefit of statins for prevention of cardiac events, treatments for functional abdominal disorders, and management of low back pain.