Antiulcer activity of Vernonia kotschyana sch. bip

M P Germano; R de Pasquale; L Iauk; E M Galati; A Keita; R Sanogo

doi:10.1016/S0944-7113(96)80047-X

Antiulcer activity of Vernonia kotschyana sch. bip

Phytomedicine. 1996 Jan;2(3):229-33. doi: 10.1016/S0944-7113(96)80047-X.

Authors

M P Germano¹, R de Pasquale, L Iauk, E M Galati, A Keita, R Sanogo

Affiliation

¹ Pharmaco-Biological Department, School of Pharmacy, University of Messina, Italy.

PMID: 23194621
DOI: 10.1016/S0944-7113(96)80047-X

Abstract

Vernonia root is a herbal remedy used in Mali folk medicine for treatment of gastritis and gastroduodenal ulcer. The clinical trial conducted in Mali on a small number of patients gave encouraging results. In our studies, the aqueous extract of Vernonia, administered before or after an ulcerogenous agent, reduces the number and severity of ethanol-induced ulcers. The extract does not produce changes in volume, pH and total acid output in pyloric-ligated animals.